منابع مشابه
Voltage Gating of Shaker K+ Channels
Ionic (Ii) and gating currents (Ig) from noninactivating Shaker H4 K+ channels were recorded with the cut-open oocyte voltage clamp and macropatch techniques. Steady state and kinetic properties were studied in the temperature range 2-22 degreesC. The time course of Ii elicited by large depolarizations consists of an initial delay followed by an exponential rise with two kinetic components. The...
متن کاملBinding Site in Shaker K Channels
We have examined the interaction between TEA and K 1 ions in the pore of Shaker potassium channels. We found that the ability of external TEA to antagonize block of Shaker channels by internal TEA depended on internal K 1 ions. In contrast, this antagonism was independent of external K 1 concentrations between 0.2 and 40 mM. The external TEA antagonism of internal TEA block increased linearly w...
متن کاملFast Inactivation in Shaker K+ Channels
Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known as "charge immobilization" (Armstrong, C.M., and F. Bezanilla. 1977. J. Gen. Physiol. 70:567-590.). Shaker H4 W434F gating currents are very s...
متن کاملDual Regulation of Voltage-Sensitive Ion Channels by PIP2
Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidylinositol 4,5-bisphosphate (PIP(2)). Among them are voltage-gated channels, which are crucial for both neuronal and cardiac excitability. Voltage-gated calcium (Cav) channels were shown to be regulated bidirectionally by PIP(2). On on...
متن کاملPIP2 PIP2 Hooray for Maxi K+
Background: Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. Methods and design: This randomized clinical trial will examine wh...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.2567